I am a molecular and cell biologist with a doctoral degree (Dr. rer. nat.) in biology from
RWTH Aachen University, earned at the Institute of Molecular Immunology and Biochemistry. I have recently added computational biology to my training through
a bioinformatics programme at CQ Mplus Academy in Berlin. My work focuses on the cellular mechanisms that
drive cancer cell survival and progression, and on cell-cell interactions in immune responses.
I am particularly interested in how these mechanisms, from cellular stress responses to
uncontrolled proliferation, could be targeted therapeutically.
I combine molecular biology with my background in immunology and cancer biology,
supported by skills in bioinformatics and data analysis.
Pools cell lines belonging to one disease and extracts the signature they share:
commonly and selectively essential genes from CRISPR screens, plus consensus up- and
down-regulated genes from expression data. Scoring combines effect size with
cross-line consistency, so single-line outliers do not dominate.
RWTH Aachen, Institute of Molecular Immunology and Biochemistry
Analysis pipeline for TurboID and BioID proximity-labeling proteomics: contaminant
handling, enrichment against the appropriate labeling control, statistical testing and
interpretation of proximal interactors.
Underlies the IRE1 interactome published in Cells (2024).
University Hospital Frankfurt, Department of Hematology
Built a CROP-seq system for cytosine and adenine deaminase base editors, from vector
design and viral transduction through to editing validation, so that guide identity and
transcriptome can be read out from the same cell.
Screening system established and handed over; wet-lab work,
not yet published.
CRISPR base editing
CROP-seq
Lentiviral transduction
Cloning
TMT proteomics with internal reference scaling
Training project, University Hospital Frankfurt
Worked through a multi-plex TMT dataset carrying a pooled reference channel and
deliberate plex-level batch differences, to show why internal reference scaling is
required before any cross-plex comparison is meaningful.
Scripted gating workflow for flow cytometry in R, written to make gating decisions
explicit and repeatable rather than clicked through by hand in a GUI.
Grew out of several years on FACSCanto and LSRFortessa.
Snakemake workflow for mtDNA sequencing from blood samples, covering read processing
through variant calling with the steps and dependencies declared rather than implied.